Liverpool head coach Jurgen Klopp makes 10 changes, with only Gomez keeping his spot in the centre of defence from the young team that beat Everton 1-0 in the FA Cup. Dejan Lovren, Joel Matip, Fabinho, Naby Keita, James Milner and long-term absentee Nathaniel Clyne make up the Reds’ injury list.
Jose Mourinho makes just three changes from the Spurs side that drew 1-1 with Middlesbrough in the FA Cup last time out. Sessegnon, Vertonghen and Dier drop to the bench, with Rose, Sanchez and Premier League debutant Tanganga taking their places in the starting lineup. Star striker Harry Kane is sidelined, along with Moussa Sissoko, Ben Davies, Hugo Lloris and Tanguy Ndombele.
Tottenham substitutes: Jan Vertonghen, Eric Dier, Oliver Skipp, Giovani Lo Celso, Ryan Sessegnon, Erik Lamela, Michel Vorm.
Tottenham XI (4-2-3-1): Paulo Gazzaniga; Japhet Tanganga, Toby Alderweireld, Davinson Sanchez, Danny Rose; Harry Winks, Christian Eriksen; Serge Aurier, Dele Alli, Son Heung-min; Lucas Moura.
Liverpool substitutes: Divock Origi, Adrian, Adam Lallana, Xherdan Shaqiri, Nathaniel Phillips, Neco Williams, Takumi Minamino.
Liverpool XI (4-3-3): Alisson; Trent Alexander-Arnold, Joe Gomez, Virgil van Dijk, Andy Robertson; Georginio Wijnaldum, Jordan Henderson, Alex Oxlade-Chamberlain; Mohamed Salah, Roberto Firmino, Sadio Mane.